Antonio Curcio M.D., Ph.D.
Date of birth: June 19th, 1976 –Naples, Italy
- Medical Doctor Degree: July, 2000 at the University School of Medicine “Federico II” of Naples with degree “magna cum laude”
- Board Certificate in Cardiology 2005 at University School of Medicine “Magna Graecia” of Catanzaro with certification “magna cum laude”
- Research Associate from January 2004 to December 2005 at DUKE University Medical College, Department of Medicine, Cell Biology and Genetics, Director: Howard A. Rockman
- Medical Biotechnologies PhD degree, University School of Medicine “Magna Graecia” of Catanzaro in 2009.
- Master degree, University School of Medicine “Magna Graecia” of Catanzaro in Interventional Cardiology in 2010.
- Assistant Professor, Magna Graecia University from 2008 to 2015
- Current Position: Associate Professor, Magna Graecia University. Competence in clinical cardiology, skills in both pharmacological and device-related management of cardiac arrhythmias and electrophysiological disorders of excitation-contraction of the heart.
- Clinical Fellowship from September 2006 to January 2008 in Electrophysiology and Cardiac Pacing Department, San Raffaele Hospital, Director: Carlo Pappone, MD, PhD
- Research Fellowship from January 2012 to December 2015 in Laboratory of Molecular Cardiology, Maugeri Foundation, Pavia University, Director: Silvia G. Priori, MD, PhD
Competence of Training:
As cardiologist, 8 years in Coronary Care Unit: admission, discharge, and follow-up of patients with acute ST-elevation myocardial infarction, unstable angina/non ST elevation myocardial infarction, decompensated heart failure, supraventricular and ventricular arrhythmias diagnosis and treatment. Three hundred left-heart-sided cardiac catheterization procedures performed per year. Specific training in Cardiac Electrophysiology. One hundred and fifty right-heart-sided cardiac catheterization procedures performed per year. First operator in central vein cannulation approaches, cephalic vein cutdown approach, single and dual chamber pacemaker implantation, single and dual chamber automated defibrillator implantation, biventricular pacemaker implantation, devices programming, clinical and electrophysiological patients’ follow-up. Invasive electrophysiologic studies followed by ablation of supraventricular and ventricular arrhythmias, trans-septal approach, atrial fibrillation ablation, CARTO and NavX cardiac electro-anatomic mapping systems application.
The focus of the research during the last eighteen years as a medical college student, as a resident student, and as researcher was the evaluation and development of new molecular targets in vascular smooth muscle cell proliferation in an experimental model of rat balloon injury aimed to prevention of pathophysiologic phenomenon of restenosis after percutaneous coronary interventions procedures. Moreover, the field of studies has been expanded during the experience in the molecular cardiology laboratory at Duke University, with acquisition of molecular biology competences in cardiac failure after myocardial hypertrophy and infarction in genetically modified mice. In particular, the molecular signalling of beta adrenergic receptor down-regulation and desensitization has been extensively investigated demonstrating for the first time that competitively displacing the BARK1/PI3K interaction via overexpression of phosphoinositide kinase domain (PIK domain) of PI3K could preserve cardiac function in a chronic model of heart failure after myocardial infarction. The field of interest in the PhD program in Medical Biotechnologies has been the evaluation of proteomic patterns modification in serum from patients affected by cardiovascular diseases related to genetic modification such as myocardial infarction and heart failure.
Current research projects are mainly focused on inherited arrhythmia syndromes, such as Brugada syndrome, Short QT syndrome, Catecholaminergic polymorphic ventricular tachycardia.
Additional fields are the emerging role of microRNAs in cardiovascular diseases and molecular mechanisms of electrogenesis in cardiac arrhythmias; responders to cardiac resynchronization therapy in heart failure.
Ongoing projects are developed on management and prophylaxis of thromboembolisms with novel oral anticoagulating agents.
Transfer of technology:
e-CRTD: an app for the doctor available on Google Play™ online store as free-of-charge download for Android
e-CRTD: an app for the doctor available on online App Store™ for iOS as free-of-charge download
- Since 2008: teacher for “Graduated course in Cardiovascular Diseases” University School of Medicine “Magna Graecia” of Catanzaro
- Since 2008: teacher for “Post-graduated course in Cardiac Electrophysiology” University School of Medicine “Magna Graecia” of Catanzaro
- 2006: co-editing of the italian version of the Dorland’s Medical Dictionary
- 2007: co-editing of the italian version of the Braunwald’s Heart Disease
- Since 2008 peer reviewer referee for the following Journals:
European Journal of Pharmacology; Circulation Journal; Journal of Cardiovascular Medicine; PLoS ONE; BioMed Research International; Journal of Cardiovascular Pharmacology and Therapeutics; The American Journal of Cardiology; Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease
Grants and Awards:
- 2002: young investigator award at the International Meeting on Myocardial Revascularization. Course Director: Mario Marzilli, MD
- 2003: grant from Italian Society of Cardiology for developing a project on modifier genes in heart failure. Course Director: Maurizio Guazzi, MD
- 2007: grant from Centro per la Lotta all’Infarto – ONLUS Foundation for developing a project on nanotechnologies and drug eluting stents. Course Director: Pier Luigi Prati, MD
- 2014: grant from Ministero della Salute RF-2011-02348444 “Inherited arrhythmias: clinical characterization, genetic geography and experimental studies in the Calabria Region isolate” in cooperation with Laboratory of Molecular Cardiology Salvatore Maugeri Foundation -University of Pavia.